AMINO ALCOHOL LIPIDOIDE AND APPLICATION THEREOF

To provide a manufacturing method of amino alcohol lipidoide by reacting amine with an epoxide terminal compound.SOLUTION: A following compound is illustrated as a specific example. The amino alcohol lipidoide can be manufactured from racemic or stereochemically pure epoxide. The amino alcohol lipid...

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Bibliographic Details
Main Authors LANGER ROBERT S, DANIEL GRIFFITH ANDERSON, KERRY PETER MAHON, CHRISTOPHER G LEVINS, KEVIN THOMAS LOVE, KATHRYN ANN WHITEHEAD
Format Patent
LanguageEnglish
Japanese
Published 28.03.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:To provide a manufacturing method of amino alcohol lipidoide by reacting amine with an epoxide terminal compound.SOLUTION: A following compound is illustrated as a specific example. The amino alcohol lipidoide can be manufactured from racemic or stereochemically pure epoxide. The amino alcohol lipidoide or a salt form thereof is preferably biodegradable and biocompatible and can be used in various drug delivery system.SELECTED DRAWING: None 【課題】アミンをエポキシド末端化合物と反応させることによる、アミノアルコールリピドイドの製造方法の提供。【解決手段】具体的な例として、下記化合物が示される。上記アミノアルコールリピドイドは、ラセミ的または立体化学的に純粋なエポキシドから調製することができる。アミノアルコールリピドイドまたはその塩形態は、好ましくは生分解性および生体適合性であり、種々の薬物送達システムにおいて用いることができる。【選択図】なし
Bibliography:Application Number: JP20180206565