4-PHENYL-4-OXOBUTANOIC ACID DERIVATIVE

• Main Authors: KITAHARA KATSUSHI, ISHIDA KYOJI, FUKAYA TAKAYUKI, KATAOKA MAYUMI, ABE TAKAAKI
• Format: Patent
• Language: English; Japanese
• Published: 14.03.2019
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

To provide a compound useful as an agent for treating/or preventing a disease caused by an abnormality in a mitochondrial function.SOLUTION: The present invention provides a 4-phenyl 4-oxobutanoic acid derivative illustrated by formula III-3 and a pharmaceutically acceptable salt thereof. The present invention provides a therapeutic agent that is applied to a disease caused by a mitochondrial function disorder, which is mitochondrial disease, neurodegenerative disease, immunologic neurological disease, brain ischemic disease, renal disease, myopathy, or cardiac disease.SELECTED DRAWING: None 【課題】ミトコンドリア機能の異常が関わる疾患の治療薬／又は予防剤として有用な化合物の提供。【解決手段】式ＩＩＩ−３で例示される４−フェニルー４−オキソブタン酸誘導体およびその製薬学的に許容される塩。適応されるミトコンドリア機能障害に起因する疾患がミトコンドリア病、神経変性疾患、免疫性神経疾患、脳虚血性疾患、腎疾患、筋疾患、又は心疾患である治療剤。【選択図】なし