PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING PAIN, CONTAINING NITROGEN-CONTAINING HETEROCYCLIC AND CARBOCYCLIC DERIVATIVE

• Main Authors: YAMAGUCHI HIROKI, YUKIMASA AKIRA, HORIGUCHI TORU, FUJIO MOTOHIRO, KANO KAZUYA, NAKAMURA KENICHIRO, INOUE TAKATSUGU
• Format: Patent
• Language: English; Japanese
• Published: 21.02.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide a pharmaceutical composition for treating or preventing a pain, containing a compound having TrkA inhibitory activity or a pharmaceutically acceptable salt thereof.SOLUTION: The present invention provides a compound represented by formula (I) or a pharmaceutically acceptable salt thereof (where =X is =O or the like, Rand Rare a hydrogen atom or the like, -A- is -NR- or the like, B is a substituted or unsubstituted aromatic carbocyclic group or the like, Ris a substituted or unsubstituted alkyl or the like, Ris a hydrogen atom or the like, -W- is -CH- or the like, -W- is -CH- or the like, Ris a substituted or unsubstituted aromatic carbocyclic group or the like, Ris a substituted or unsubstituted aromatic heterocyclic group or the like, Ris a substituted or unsubstituted alkyl or the like), and a pharmaceutical composition containing the same, particularly, a pharmaceutical composition for treating or preventing a pain.SELECTED DRAWING: None 【課題】本発明は、ＴｒｋＡ阻害活性を有する化合物またはその製薬上許容される塩を含有する、疼痛の治療および／または予防用医薬組成物を提供する。【解決手段】式（Ｉ）：（式中、＝Ｘは＝Ｏ等、Ｒ５およびＲ５Ａは水素原子等、−Ａ−は−ＮＲ１−等、Ｂは置換若しくは非置換の芳香族炭素環式基等、Ｒ１は置換若しくは非置換のアルキル等、Ｒ２は水素原子等、−Ｗ−は−ＣＨ２−等、−ＷＡ−は−ＣＨ２−等、Ｒ１３は置換若しくは非置換の芳香族炭素環式基等、Ｒ１４は置換若しくは非置換の芳香族複素環式基等、Ｒ１５は置換若しくは非置換のアルキル等）で示される化合物またはその製薬上許容される塩、およびそれらを含有する医薬組成物、特に、疼痛の治療および／または予防用医薬組成物を提供する。【選択図】なし