SILODOSIN-CONTAINING ORAL SOLID PREPARATION EXCELLENT IN LIGHT STABILITY

• Main Authors: KIMURA SHINICHIRO, ISSHIKI NOBUYUKI, SHIBATA YUSUKE
• Format: Patent
• Language: English; Japanese
• Published: 24.01.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide an oral solid preparation excellent in light stability in which decomposition of silodosin due to light is inhibited.SOLUTION: The present invention relates to an oral solid preparation, such as an orally disintegrating tablet, which separately contains each of a photostabilizer and a granular drug that contains silodosin. Preferably, the photostabilizer is selected from the group consisting of titanium oxide, yellow iron oxide, yellow iron sesquioxide, brown iron oxide, iron sesquioxide, Food Yellow No. 4, Food Yellow No. 5, Food Yellow No. 4, aluminum lake, Food Red No. 2, Food Red No. 3 and Food Red No. 102.SELECTED DRAWING: None 【課題】 本発明は、シロドシンの光による分解を抑制した光安定性に優れた経口固形製剤を提供すること。【解決手段】 本発明は、シロドシンを含有する薬物顆粒と光安定化剤をそれぞれ別個に含有する口腔内崩壊錠等の経口固形製剤に関するものである。前記光安定化剤は、酸化チタン、黄酸化鉄、黄色三二酸化鉄、褐色酸化鉄、三二酸化鉄、食用黄色４号、食用黄色５号、食用黄色４号アルミニウムレーキ、食用赤色２号、食用赤色３号及び食用赤色１０２号からなる群から選択されることが好ましい。【選択図】 なし