OIL-BASED ADJUVANTS

• Main Authors: JULIE LYDIA FITZPATRICK, DUNCAN MWANGI, MICHAEL CHRISTOPHER FONTAINE, KREBS RICHARD LEE, LAUREN WILMES, KAORI MOHR, SARAH A SALMON, DENNIS L FOSS, PAUL JOSEPH DOMINOWSKI, SANGITA MEDIRATTA, GUILLERMO GALLO, JOHN MORGAN HARDHAM, SHARATH K RAI, SANDRA ANN MARIE LIGHTLE, SHAUNAK VORA, DAVID GEORGE EMSLIE SMITH, ANITA DOROTA JAGLARZ, WILLIAM DONACHIE, SUMAN MAHAN
• Format: Patent
• Language: English; Japanese
• Published: 27.12.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide adjuvant formulations for use in immunogenic compositions and vaccine compositions to enhance immune responses to antigens.SOLUTION: Disclosed herein is an adjuvant formulation comprising oil and aqueous phases, where the oily phase corresponds to at least 50 v/v% of the formulation, the formulation comprises at least one of monophosphoryl lipid A (MPL-A) or an analog thereof and an immunostimulating oligonucleotide in the proviso that: a) when the immunostimulating oligonucleotide is not present, the formulation comprises: i. a poly I:C, a glycolipid, and, optionally, a quaternary amine; or ii. a polycationic carrier; and b) when the monophosphoryl lipid A (MPL-A) or the analog thereof is not present, the formulation comprises a source of aluminum.SELECTED DRAWING: None 【課題】免疫原性組成物およびワクチン組成物中で使用するための抗原への免疫応答を増強するアジュバント製剤の提供。【解決手段】油相および水相を含むアジュバント製剤であって、前記油相が、前記製剤の少なくとも５０％ｖ／ｖを占め、前記製剤が、モノホスホリルリピドＡ（ＭＰＬ−Ａ）もしくはその類似体および免疫刺激性オリゴヌクレオチドのうちの少なくとも一方を含み、ただしａ）前記免疫刺激性オリゴヌクレオチドが、存在しない場合、前記製剤が、ｉ．ポリＩ：Ｃ、糖脂質、および所望により第四級アミン、またはｉｉ．ポリカチオン性担体を含み、ｂ）前記モノホスホリルリピドＡ（ＭＰＬ−Ａ）もしくはその類似体が、存在しない場合、前記製剤が、アルミニウムの供給源を含むこと、を条件とする、アジュバント製剤。【選択図】なし