1-[2[(2,4-DIMETHYLPHENYLSULFANYL)-PHENYL]PIPERAZINE AS COMPOUND WITH COMBINED SEROTONIN REUPTAKE 5-HT3 AND 5-HT1A ACTIVITY FOR TREATMENT OF COGNITIVE IMPAIRMENT

To provide a compound extremely useful for a treatment of cognitive impairment in depression patients.SOLUTION: 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine has strong activity on SERT, 5-HTand 5-HT, and is useful for a treatment of cognitive impairment, especially cognitive impairment in dep...

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Main Authors FALDT ANDRE, MOORE NICHOLAS, ROCK MICHAEL HAROLD, STENSBOEL TINE BRYAN, JOERGENSEN MORTEN, HOLM RENE, BANG-ANDERSEN BENNY, LOPEZ DE DIEGO HEIDI, BRODERSEN JOERGEN, MEALY MICHAEL J, MOERK ARNE, RINGGAARD LONE MUNCH
Format Patent
LanguageEnglish
Japanese
Published 20.12.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide a compound extremely useful for a treatment of cognitive impairment in depression patients.SOLUTION: 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine has strong activity on SERT, 5-HTand 5-HT, and is useful for a treatment of cognitive impairment, especially cognitive impairment in depression patients.SELECTED DRAWING: None 【課題】うつ病患者における認識機能障害の治療に格別に有用な化合物を提供すること。【解決手段】１−［２−（２，４−ジメチルフェニルスルファニル）−フェニル］ピペラジンは、ＳＥＲＴ、５−ＨＴ３および５−ＨＴ１Ａに及ぼす強力な活性を呈し、そのようなものとして、認識機能障害の治療、特にはうつ病患者における認識機能障害の治療に有用であり得る。【選択図】なし
Bibliography:Application Number: JP20180150653