NITROGEN-CONTAINING CONDENSATION HETEROCYCLIC COMPOUND

• Main Authors: MASUDA SEIJI, SHIMONO RIE, MATSUDA DAISUKE, YAMAMOTO SHUJI
• Format: Patent
• Language: English; Japanese
• Published: 20.12.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide a novel compound or a pharmaceutically acceptable salt thereof useful for the therapy or prevention of diseases such as autism spectrum disorder, fragile X syndrome, schizophrenia, dipolar disorder, depression, anxiety disorder, dementia, pain, drug-alcohol dependence, convulsion, cerebrovascular disorder, cerebral palsy, myeloparalysis, posttraumatic complication, multiple sclerosis, amyotrophic lateral sclerosis, and stiff-man syndrome, based on a GABAB acceptor PAM effect.SOLUTION: Provided is a compound represented by formula (I), or a pharmaceutically acceptable salt thereof.SELECTED DRAWING: None 【課題】ＧＡＢＡＢ受容体ＰＡＭ作用に基づいた、自閉症スペクトラム障害、脆弱性Ｘ症候群、統合失調症、双極性障害、うつ病、不安障害、認知症、疼痛、薬物・アルコール依存症、痙攣、脳血管障害、脳性麻痺、脊髄麻痺、外傷後遺症、多発性硬化症、筋萎縮性側索硬化症、ｓｔｉｆｆ−ｍａｎ症候群等の疾患の治療又は予防に有用な新規化合物又はその医薬上許容される塩を提供することである。【解決手段】式（Ｉ）で示される化合物又はその医薬上許容される塩。【化１】【選択図】なし