COMPOUNDS AND USES THEREOF FOR MODULATION OF HEMOGLOBIN

PROBLEM TO BE SOLVED: To provide compounds and pharmaceutical compositions suitable as allosteric modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that should benefit from tissue and/or cel...

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Main Authors JASON R HARRIS, LI ZHE, XU QING, BRIAN W METCALF, STEPHEN L GWALTNEY II, CALVIN W YEE
Format Patent
LanguageEnglish
Japanese
Published 29.11.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide compounds and pharmaceutical compositions suitable as allosteric modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that should benefit from tissue and/or cellular oxygenation.SOLUTION: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that should benefit from tissue and/or cellular oxygenation.SELECTED DRAWING: None 【課題】本発明は、ヘモグロビンのアロステリック修飾剤として好適な化合物及び医薬組成物、それらの調製のための方法及び中間体、並びにヘモグロビンにより媒介される疾患並びに組織及び／又は細胞の酸素供給により利益を受けるであろう疾患の治療におけるそれらの使用方法を与える。【解決手段】ヘモグロビンの修飾剤として好適な化合物及び医薬組成物、それらの調製のための方法及び中間体、並びにヘモグロビンにより媒介される疾患並びに組織及び／又は細胞の酸素供給により利益を受けるであろう疾患の治療におけるそれらの使用方法が本明細書に提供される。【選択図】なし
Bibliography:Application Number: JP20180167981