INDAZOLE INHIBITORS OF WNT SIGNALING PATHWAY AND THERAPEUTIC USES THEREOF

PROBLEM TO BE SOLVED: To provide indazole compounds in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events media...

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Bibliographic Details
Main Authors DAVID MARK WALLACE, HOOD JOHN, SUNIL KUMAR KC
Format Patent
LanguageEnglish
Japanese
Published 29.11.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide indazole compounds in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components.SOLUTION: The compounds are represented by the formula 2 or the like.SELECTED DRAWING: None 【課題】Wnt経路シグナル伝達の活性化によって特徴付けられる障害（例えば、癌、異常な細胞増殖、血管形成、アルツハイマー病、肺疾患及び骨関節症））、Wnt経路シグナル伝達によって仲介される細胞事象の調節、並びにWnt経路の及び／又は1つもしくは複数のWntシグナル伝達成分の突然変異又は調節不全による遺伝疾患及び神経学的状態／障害／疾患の治療における、インダゾール化合物の提供。【解決手段】式2等で例示される化合物。【選択図】なし
Bibliography:Application Number: JP20180166480