PENTOSIDINE PRODUCTION INHIBITOR

• Main Authors: YAGI MASAYUKI, SHINODA KAZUTOSHI
• Format: Patent
• Language: English; Japanese
• Published: 29.11.2018
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

PROBLEM TO BE SOLVED: To provide inhibitors for the production of Pentosidine which has drawn attention in recent years as a marker of diabetic nephropathy and osteoporosis among final products of saccharification reaction of protein which are said to be involved in aging phenomenon, dementia, cancer, hypertension, arteriosclerosis and the like.SOLUTION: To solve the above-mentioned subject, the present invention provides a Pentosidine production inhibitor containing as an active ingredient at least one or more selected from luteolin-7-O-glucoside, tricine, catechin, astragalin, isoquercitrin, rutin, gallic acid and ellagic acid. The food and drinks, health foods, food additives, medicines, cosmetics, and quasi drugs which contain such Pentosidine production inhibitor are also provided.SELECTED DRAWING: Figure 2 【課題】蛋白質の糖化反応最終生成物は、老化現象、認知症、癌、高血圧、動脈硬化症などに関与しているといわれている。そのなかで、ペントシジン（Ｐｅｎｔｏｓｉｄｉｎｅ）は糖尿病性腎症や骨粗しょう症のマーカーとして近年注目されている。本発明はペントシジンの生成阻害剤を提供することを課題とする。【解決手段】上記課題を解決するために、ルテオリン−７−Ｏ−グルコシド、トリシン、カテキン、アストラガリン、イソクエルシトリン、ルチン、没食子酸及びエラグ酸より選ばれる少なくとも１種以上を有効成分として含有するペントシジン生成阻害剤を提供する。また、係るペントシジン生成阻害剤を含有する飲食品、健康食品、食品添加物、医薬品、化粧品、医薬部外品を提供する。【選択図】図２