FCγ RECEPTOR IIB VARIANT

• Main Authors: UWE JACOB, DOMINIK TER MEER, PETER SONDERMANN, THOMAS POHL, RENO WINTER
• Format: Patent
• Language: English; Japanese
• Published: 29.11.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a human FcγRIIB protein having excellent CMC properties.SOLUTION: The present invention provides a Fcγ receptor IIB variant protein coded by a nucleic acid having a specific base equence; a vector containing the nucleic acid sequence, and a host cell containing the nucleic acid sequence or the vector; and a pharmaceutical composition containing the Fcγ receptor IIB variant protein and a method of producing the pharmaceutical composition.SELECTED DRAWING: None 【課題】優れたCMC特性を有するヒトFcγRIIBタンパク質を提供する。【解決手段】特定の塩基配列を有する核酸にコードされるＦｃγ受容体ＩＩＢ変異体タンパク質を提供する。前記核酸配列を含むベクター、および前記核酸配列または前記ベクターを含む宿主細胞をも提供する。さらに前記Ｆｃγ受容体ＩＩＢ変異体タンパク質を含む薬学的組成物および薬学的組成物を製造方法を提供する。【選択図】なし