MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

PROBLEM TO BE SOLVED: To provide novel macrocyclic compounds for treatment of microbial infections.SOLUTION: The macrocyclic compounds have broad spectrum bioactivity, and act by inhibition of bacterial type 1 signal peptidase (SpsB), which is an essential protein in bacteria.SELECTED DRAWING: None...

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Bibliographic Details
Main Authors PRASUNA PARASELLI, PETER ANDREW SMITH, TUCKER CURRAN ROBERTS, ROBERT I HIGUCHI, DAVID CAMPBELL
Format Patent
LanguageEnglish
Japanese
Published 22.11.2018
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide novel macrocyclic compounds for treatment of microbial infections.SOLUTION: The macrocyclic compounds have broad spectrum bioactivity, and act by inhibition of bacterial type 1 signal peptidase (SpsB), which is an essential protein in bacteria.SELECTED DRAWING: None 【課題】微生物の感染の処置のための新規な大環状化合物の提供。【解決手段】当該大環状化合物は広域スペクトルの生物活性を持ち、細菌中の必須なタンパク質である、１型細菌シグナルペプチダーゼ（ＳｐｓＢ）の阻害によって作用する。【選択図】なし
Bibliography:Application Number: JP20180135357