METHODS FOR TREATING NEOPLASIA

• Main Authors: WEN JINGHAI, PETER RHODE, WONG HING C, XU WENXIN
• Format: Patent
• Language: English; Japanese
• Published: 08.11.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide methods for treating cancer.SOLUTION: Disclosed herein is a method for ameliorating cancer in a subject comprising administering an effective amount of IL-2 fusion protein and one or more therapeutic agents to a subject in need thereof thereby ameliorating cancer. In one embodiment, the IL-2 fusion protein does not specifically target or bind to the cancer. In another embodiment, the IL-2 fusion protein comprises a T cell receptor (TCR) domain. In yet another embodiment, the T cell receptor domain is a single chain T cell receptor.SELECTED DRAWING: Figure 1 【課題】癌を治療する方法の提供。【解決手段】有効量のＩＬ−２融合タンパク質および１つまたは複数の治療薬を、それを必要とする被験者に投与し、これにより癌を改善することを含む、被験者において癌を改善する方法。前記ＩＬ−２融合タンパク質が癌を特異的に標的としないまたは癌に結合しない、前記方法。前記ＩＬ−２融合タンパク質がＴ細胞受容体（ＴＣＲ）ドメインを含む、前記方法。前記Ｔ細胞受容体ドメインが一本鎖Ｔ細胞受容体である、前記方法。【選択図】図１