PEPTIDE COMPOUND

• Main Authors: ASAMI TAIJI, NIIDA AYUMU
• Format: Patent
• Language: English; Japanese
• Published: 01.11.2018
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide a novel peptide compound having high GLP-1 receptor/GIP receptor co-agonist activity and useful as an agent for the prophylaxis or treatment of obesity and the like.SOLUTION: The present invention provides H-Tyr-Aib-Glu-Gly-Thr-α-MePhe-Thr-Ser-Asp-Tyr-Aib-Lys-Tyr-Leu-Asp-Lys-Gln-Ala-Gln-Ala-Glu-Phe-Val-Lys-Trp-Leu-Leu-Lys-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-Lys-NHor salt thereof.SELECTED DRAWING: None 【課題】高いGLP-1受容体/GIP受容体コアゴニスト活性を有し、肥満症などの予防・治療剤として有用な新規なペプチド化合物を提供する。【解決手段】Ｈ−Ｔｙｒ−Ａｉｂ−Ｇｌｕ−Ｇｌｙ−Ｔｈｒ−α-ＭｅＰｈｅ−Ｔｈｒ−Ｓｅｒ−Ａｓｐ−Ｔｙｒ−Ａｉｂ−Ｌｙｓ−Ｔｙｒ−Ｌｅｕ−Ａｓｐ−Ｌｙｓ−Ｇｌｎ−Ａｌａ−Ｇｌｎ−Ａｌａ−Ｇｌｕ−Ｐｈｅ−Ｖａｌ−Ｌｙｓ−Ｔｒｐ−Ｌｅｕ−Ｌｅｕ−Ｌｙｓ−Ｇｌｙ−Ｇｌｙ−Ｐｒｏ−Ｓｅｒ−Ｓｅｒ−Ｇｌｙ−Ａｌａ−Ｐｒｏ−Ｐｒｏ−Ｐｒｏ−Ｓｅｒ−Ｌｙｓ−ＮＨ２またはその塩。【選択図】なし