IMPROVED DEPOT FORMULATIONS

• Main Authors: WRIGHT JEREMY C, FELIX THEEUWES, STEFANIA SJOBECK, KEITH E BRANHAM, GIBSON JOHN W
• Format: Patent
• Language: English; Japanese
• Published: 11.10.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide formulations and methods that provide controlled delivery of biologically active substances with low toxicity.SOLUTION: Disclosed are formulations and related methods that comprise a non-polymeric, non-water soluble high viscosity liquid carrier material having a viscosity of at least 5,000 cP at 37°C. that does not crystallize neat under ambient or physiological conditions; a specified linear polymer comprising lactide repeat units; and one or more solvents that have a solvent capacity. Preferably, the formulations comprise sucrose acetate isobutyrate (SAIB), poly (lactide-co-glycolide) (PLGA), and proper solvents, preferably NMP. Examples of drugs are risperidone and naltrexone.SELECTED DRAWING: None 【課題】生物活性物質の制御された送達を提供する毒性の低い製剤および方法の提供。【解決手段】37℃で少なくとも5,000 cPの粘度を有し、外界条件または生理的条件下でそのままでは結晶化しない、非ポリマー性で非水溶性の高粘性液体キャリア材料；ラクチド繰り返し単位を含む特定の線状ポリマー；およびある溶媒能力を有する1つまたは複数の溶媒を含む製剤および関連する方法が開示される。好ましくは、前記製剤は、イソ酪酸酢酸スクロース(SAIB)、ポリ(ラクチド-コ-グリコリド)(PLGA)および適切な溶媒、好ましくはNMPを含む。薬物の例は、リスペリドンおよびナルトレキソンである。【選択図】なし