ORAL DISINTEGRATING TABLET WITH IMPROVED CHEMICAL STABILITY AND FEELING OF INGESTION OF THE RAW DRUG

• Main Authors: GOCHOMORI KAZUHIRO, TANIGUCHI TOSHIYA
• Format: Patent
• Language: English; Japanese
• Published: 20.09.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide an oral disintegrating tablet with a remarkably improved effect of chemical stability and feeling of ingestion such as bitterness of the raw drug such as silodosin.SOLUTION: An oral disintegrating tablet is provided that contains coated granules in which granules containing a raw drug such as silodosin in which nuclear particles are coated around the outside thereof with a coating layer are further coated with a coating layer comprising a non-enteric polymer. The granules comprising the raw drug are coated with 0.5 to 2.0 mass% of the non-enteric polymer with respect to the total weight of the uncoated drug, or preferably 2.0 to 14.0 mass%. The non-enteric polymer is a gastric-soluble polymer or water-insoluble polymer.SELECTED DRAWING: None 【課題】シロドシン等の原薬の化学的な安定性や苦味等の服用感が顕著に改善された効果を有する口腔内崩壊錠を提供すること。【解決手段】核粒子の周囲がコーティング層で被覆されていることを特徴とするシロドシン等の原薬を含む顆粒が、非腸溶性高分子を含むコーティング層で更に被覆されていることを特徴とする被覆顆粒、を含有する口腔内崩壊錠を提供すること。好ましくは素錠全重量に対して２．０〜１４．０重量％の、原薬を含む顆粒が、素錠全重量に対して０．５〜２．０重量％の非腸溶性高分子で被覆されていることを特徴とする被覆顆粒を含有し、非腸溶性高分子は胃溶性高分子又は水不溶性高分子である。【選択図】なし