METHODS FOR PREDICTING PROGNOSIS OF RENAL CELL CARCINOMA

• Main Authors: ARAI SHIGESATO, TIAN YING, KANAI YAE
• Format: Patent
• Language: English; Japanese
• Published: 13.09.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide methods for detecting risk of poor prognosis of renal cell carcinoma comprising detection of DNA methylation level.SOLUTION: The invention provides a method for detecting risk of poor prognosis of renal cell carcinoma, comprising the steps of: preparing a genomic DNA derived from a renal tissue of a subject; detecting DNA methylation level of at least one site selected from specific sites of the prepared genomic DNA; and classifying the subject into poor prognostic group when the detected DNA methylation level is recognized as a highly methylated level.SELECTED DRAWING: None 【課題】ＤＮＡメチル化レベルを検出することを含む、腎細胞癌の予後不良リスク検出法。【解決手段】前記腎細胞癌の予後不良リスク検出する方法であって、被験体の腎臓組織由来のゲノムＤＮＡを調製する工程、及び調整した前記ゲノムＤＮＡについて、特定のサイトから選択される少なくとも一の前記サイトのＤＮＡメチル化レベルを検出し、検出したＤＮＡメチル化レベルを高メチル化状態であると認めた場合に、前記被験体を予後不良群に分類する方法。【選択図】なし