MICROSPHERES USEFUL FOR THERAPEUTIC VASCULAR EMBOLIZATION

• Main Authors: BARBARA DE GIOANNIS, JAMES KROM, MARION PIERRE, PHILIPPE REB
• Format: Patent
• Language: English; Japanese
• Published: 06.09.2018
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; WORKING-UP

PROBLEM TO BE SOLVED: To provide methods of producing microspheres having a better yield productivity and better uniformity or purity, capable of providing optimized embolic effects.SOLUTION: This invention relates to microspheres, comprising: a copolymer (a) of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit; and a crosslinked gelatin substitute (b). The microsphere exhibits, in a 1H NMR spectrum, a first peak from about 3.5 ppm to about 4 ppm, a second peak from about 3 ppm to about 3.5 ppm, and a third peak from about 1 ppm to about 1.5 ppm; and (i) the integration ratio of the second peak to the first peak is from 0.50 to about 0.65, (ii) the integration ratio of the third peak to the first peak is from 0.61 to about 0.75, or (iii) a combination of (i) and (ii).SELECTED DRAWING: None 【課題】最適化された塞栓効果を有する微粒子を提供すると共に、より優れた収量の生産性、均一性、又は純度で微粒子を製造する方法を提供する。【解決手段】（a）N-トリス-ヒドロキシメチルメチルアクリルアミド単量体単位、ジエチルアミノエチルアクリルアミド単量体単位、及びN,N-メチレン-ビス-アクリルアミド単量体単位を含む共重合体成分、並びに（b）架橋されたゼラチン成分を含む微粒子。該微粒子は、1H NMRスペクトルにおいて、約3.5ppm〜約4ppmの第1のピーク、約3ppm〜約3.5ppmの第2のピーク、及び約1ppm〜約1.5ppmの第3のピークを示し；かつ、（i）該第2のピーク対第1のピークの積分比は、0.50〜約0.65であり、（ii）該第3のピーク対第1のピークの積分比は、0.61〜約0.75であり、又は、（iii）（i）、及び（ii）の組み合わせである。【選択図】なし