IMIDAZO[4,5-C]PYRIDINE DERIVATIVES AND PYRROLO[2,3-C]PYRIDINE DERIVATIVES AS SSAO INHIBITORS

• Main Authors: EDWARD SAVORY, LEE PATIENT, DAVID EVANS, IAIN SIMPSON, MAX ESPENSEN
• Format: Patent
• Language: English; Japanese
• Published: 06.09.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide inhibitors of semicarbazide-sensitive amine oxidase (SSAO) activity useful in treatment of inflammation, inflammatory disease, immune disease or autoimmune disease, or inhibition of tumor growth.SOLUTION: The invention provides a pyrrolo[2,3-c]pyridine compound, such as 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridine-2-yl]pyridine and 1-cyclopropyl-4-{1-phenyl-1H-pyrrolo[2,3-c]pyridine-2-yl}-1,2-dihydropyridine-2-one, or pharmaceutically acceptable salts thereof, or N-oxides of them.SELECTED DRAWING: None 【課題】炎症、炎症性疾患、免疫疾患、または自己免疫疾患の治療、または腫瘍増殖の阻害において有用であるセミカルバジド感受性アミンオキシダーゼ（ＳＳＡＯ）活性の阻害剤の提供。【解決手段】４−［１−（４−クロロフェニル）−１Ｈ−ピロロ［２，３−ｃ］ピリジン−２−イル］ピリジン、１−シクロプロピル−４−｛１−フェニル−１Ｈ−ピロロ［２，３−ｃ］ピリジン−２−イル｝−１，２−ジヒドロピリジン−２−オン等の、ピロロ［２，３−ｃ］ピリジン化合物もしくはその医薬的に許容可能な塩、またはそれらのＮ−オキシド。【選択図】なし