LONG LIFE POLYPEPTIDE BINDING MOLECULES

• Main Authors: RALF LUTTERBUESE, PATRICK HOFFMANN, TOBIAS RAUM, MARKUS MUENZ, KUFER PETER, JOHANNES BROZY, KVESIC MAJK
• Format: Patent
• Language: English; Japanese
• Published: 06.09.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide binding molecules comprising a half-life extending domain which shows an extended serum half-life compared to binding molecules not comprising a half-life extending domain.SOLUTION: A binding molecule comprises at least three binding domains included in at least one polypeptide chain, where (a) the first domain is a binding domain which is capable of binding to a cell surface molecule on a target cell, (b) the second domain is a binding domain which is capable of binding to the T cell CD3 receptor complex, and (c) the third domain is a binding domain which is capable of binding to serum albumin, where the third domain is positioned at the C-terminus of the second domain.SELECTED DRAWING: None 【課題】半減期延長ドメインを含まない結合分子と比較して延長された血清半減期を示す半減期延長ドメインを含む結合分子の提供。【解決手段】少なくとも1つのポリペプチド鎖中に含まれる少なくとも3つの結合ドメインを含む結合分子であって、（a）第1のドメインが、標的細胞上の細胞表面分子に結合することができる結合ドメインであり、（b）第2のドメインが、T細胞CD3受容体複合体に結合することができる結合ドメインであり、かつ、（c）第3のドメインが、血清アルブミンに結合することができる結合ドメインであり、該第3のドメインが、第2のドメインのC末端に位置する、結合分子。【選択図】なし