LABELING SUBSTANCE, IMMUNOLOGICAL MEASURING METHOD, REAGENT FOR IMMUNOLOGICAL MEASUREMENT, ANALYTE MEASURING METHOD, ANALYTE MEASURING KIT, AND LATERAL FLOW TYPE CHROMATOGRAPHIC TEST STRIP

• Main Authors: MATSUMURA YASUSHI, NITTA RYUZO, ENOMOTO YASUSHI
• Format: Patent
• Language: English; Japanese
• Published: 30.08.2018
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

PROBLEM TO BE SOLVED: To provide a labeling substance capable of carrying out high sensitive determination applicable to immunological measurement without requiring any special equipment or addition of a work step, which is superior in sensitivity, durability, and visibility.SOLUTION: The labeling substance has a resin-metal complex 100 having a structure in which a metal particles 20 are immobilized on resin particles 10. The resin-metal complex 100 includes resin particles 10 and metal particles 20, which has either composition of (A) average particle diameter of the resin-metal complex 100 is 300nm or more, or (B) average particle diameter of metal particles 20 is within a range of 20-70nm. The metal particles 20 include metal particles having a part embedded in the resin particles 10 and a part exposed outside of the resin particle 10.SELECTED DRAWING: Figure 1 【課題】 免疫学的測定に使用可能で、感度、耐久性及び視認性に優れ、かつ、特別な装置や作業工程の追加を必要とせずに高感度な判定を可能とする標識物質を提供する。【解決手段】 標識物質は、樹脂粒子１０に金属粒子２０が固定化された構造を有する樹脂−金属複合体１００を有する。樹脂−金属複合体１００は、樹脂粒子１０と金属粒子２０とを備え、（Ａ）樹脂−金属複合体１００の平均粒子径が３００ｎｍを超える、又は（Ｂ）金属粒子２０の平均粒子径が２０ｎｍを超え７０ｎｍ未満の範囲内である、のいずれかの構成を備えており、金属粒子２０が、樹脂粒子１０内に埋包された部位及び樹脂粒子１０外に露出した部位を有する金属粒子を含んでいる。【選択図】 図１