IMIDAZOLE DERIVATIVE

• Main Authors: SAITO YASUHIRO, SAKA HITOSHI, WATANABE HITOSHI, ISOBE YOSHIAKI
• Format: Patent
• Language: English; Japanese
• Published: 30.08.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide a compound useful as a therapeutic agent of a disease associated with Toll-like Receptor (TLR) 2 and a pharmaceutical composition containing the compound.SOLUTION: The present invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof [where A is a hydrogen atom or Calkyl, B is a hydrogen atom or Calkyl, Q is Caryl, 5-10 membered heteroaryl or the like, W is formula (W-1), formula (W-2) or the like, R, R, Rand Rare a hydrogen atom, Calkyl or the like, -L-Ris -bond-R, -O-Ror the like, Ris a hydrogen atom, Calkyl or the like].SELECTED DRAWING: None 【課題】Ｔｏｌｌ様受容体（Ｔｏｌｌ−ｌｉｋｅ Ｒｅｃｅｐｔｏｒ； ＴＬＲ）２が関与する疾患の治療剤として有用な化合物及び当該化合物を含む医薬品組成物の提供。【解決手段】式（１）で表される化合物又はその製薬学的に許容される塩。［式中、Ａは水素原子又はＣ１−６アルキルを表し、Ｂは水素原子又はＣ１−６アルキルを表し、ＱはＣ６−１０アリール、５〜１０員のヘテロアリール等を表し、Ｗは式（Ｗ−１）、式（Ｗ−２）等を表し、ＲＡ、ＲＢ、ＲＣ及びＲＤは水素原子、Ｃ１−６アルキル等を表し、−Ｌ−ＲＥは−結合−ＲＥ、−Ｏ−ＲＥ等を表し、ＲＥは水素原子、Ｃ１−６アルキル等を表す］【選択図】 なし