ACETAMINOPHEN CONJUGATES, COMPOSITIONS AND METHODS OF USE THEREOF

PROBLEM TO BE SOLVED: To provide acetaminophen conjugates, and to provide compositions and methods of use thereof.SOLUTION: Acetaminophen conjugates are provided, which have an acetaminophen moiety covalently linked to a second moiety. The conjugates provided may have one or more advantageous proper...

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Bibliographic Details
Main Authors BLEY KEITH R, BERND JANDELEIT
Format Patent
LanguageEnglish
Japanese
Published 23.08.2018
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide acetaminophen conjugates, and to provide compositions and methods of use thereof.SOLUTION: Acetaminophen conjugates are provided, which have an acetaminophen moiety covalently linked to a second moiety. The conjugates provided may have one or more advantageous properties, including increased water solubility as compared to acetaminophen, reduced toxicity profile as compared to acetaminophen and an altered pharmacokinetic profile. Formulations comprising the conjugates are also provided, as well as methods of using the conjugates and kits comprising the conjugates.SELECTED DRAWING: None 【課題】アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法を提供すること。【解決手段】第２の部分に共有結合しているアセトアミノフェン部分を有するアセトアミノフェンコンジュゲートを提供する。提供するコンジュゲートは、アセトアミノフェンと比較して高い水溶解度、アセトアミノフェンと比較して低い毒性プロファイル、および改変された薬物動態プロファイルを包含する１つまたは複数の有利な特性を有し得る。このコンジュゲートを使用する方法およびこのコンジュゲートを含むキットと同様に、このコンジュゲートを含む製剤も提供する。【選択図】なし
Bibliography:Application Number: JP20180067394