PHARMACEUTICAL COMPOSITION

• Main Authors: TARAO AKIKO, SEKI MASANORI, SARUTA KUNIO, ISHIBUCHI SEIGOU, HONJO TAKASHI, AOYAMA JIYOSEI, OGATA SHINGO, HAMADA MAIKO, MOROKUMA KENJI, MATOBA SENTOKU, KAWADA ATSUSHI, MATSUDAIRA TETSUJI, FUJIE NAOTO
• Format: Patent
• Language: English; Japanese
• Published: 19.07.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide a pharmaceutical composition comprising as an active ingredient a novel low molecular weight compound which inhibits the production of inducible MMPs, particularly MMP-9, rather than the production of constant MMP-2.SOLUTION: The pharmaceutical composition comprises a compound represented by the following formula and has a specific chemical structure as an active ingredient. The pharmaceutical composition is useful as a prophylactic and/or therapeutic agent for autoimmune diseases such as rheumatoid arthritis, inflammatory bowel diseases (ulcerative colitis, Crohn's disease) and osteoarthritis.SELECTED DRAWING: None 【課題】恒常型のＭＭＰ−２の産生よりも誘導型のＭＭＰｓ、特にＭＭＰ−９の産生を抑制する新規な低分子化合物を有効成分として含有する医薬組成物の提供。【解決手段】以下の式で代表される化合物を含む、特定の化学構造を有する化合物を有効成分として含有する医薬組成物。当該医薬組成物は、関節リウマチ等の自己免疫疾患、炎症性腸疾患（潰瘍性大腸炎、クローン病）、変形性関節症の予防及び／又は治療薬として有用である。【選択図】なし