TRPM8 INHIBITOR

• Main Authors: KIJIMA YOSHIRO, MUTAI YOSUKE, FUSHIMI NOBUHIKO, HIRASAWA HIDEAKI, TANADA FUMIYA, KOBAYASHI JUNICHI
• Format: Patent
• Language: English; Japanese
• Published: 28.06.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide a pharmaceutical composition containing a pyrazole derivative having a TRPM8 inhibitory action or a pharmacologically acceptable salt thereof.SOLUTION: A pharmaceutical composition contains a pyrazole derivative represented by formula (I), or a pharmacologically acceptable salt thereof (ring A is aryl or the like; X is CRor N; Rand Rindependently represent H, halogen, alkyl or the like; Ris H, halogen and the like, Ris H, alkyl and the like, ring B is aryl or a heterocycle; Ris H, alkyl or the like; Ris H, C(=O) Ror the like; Ris H or alkyl; Ris H, F, hydroxy or the like; Ris H, F or alkyl; Ris H, halogen or the like; Ris hydroxy, alkyl or the like; and n is an integer of 0-2).SELECTED DRAWING: None 【課題】TRPM8阻害作用を有するピラゾール誘導体又はその薬理学的に許容される塩を含有する医薬組成物の提供。【解決手段】式（Ｉ）で表されるピラゾール誘導体、又はその薬理学的に許容される塩を含有する医薬組成物。（環Ａはアリール等；ＸはＣＲ4a又はＮ；Ｒ1及びＲ2は夫々独立にＨ、ハロゲン、アルキル等；Ｒ3はＨ、ハロゲン等、Ｒ4はＨ、アルキル等、環Ｂはアリール又はヘテロ環；Ｒ5はＨ、アルキル等；Ｒ6aはＨ、Ｃ（＝Ｏ）Ｒ９等；Ｒ６ｂはＨ又はアルキル；Ｒ7aはＨ、Ｆ、ヒドロキシ等；Ｒ7bはＨ、Ｆ又はアルキル；Ｒ8はＨ、ハロゲン等；Ｒ９はヒドロキシ、アルキル等；ｎは０〜２の整数）【選択図】なし