COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE

• Main Authors: STEVEN DURRANT, O'DONNELL MICHAEL, MANINDER PANESAR, JIMENEZ JUAN-MIGUEL, GORKA ETXEBARRIA I JARDI, HEATHER TWIN, DEAN BOYALL, JOANNE PINDER, PIERRE-HENRI STORCK, KAY DAVID, DAVIS CHRIS, CHARRIER JEAN-DAMIEN, DONALD MIDDLETON, STUDLEY JOHN, FRANCOISE PIERARD, KNEGTEL RONALD, REBECCA DAVIS, FRAYSSE DAMIEN, NADIA AHMAD, DAVID SHAW
• Format: Patent
• Language: English; Japanese
• Published: 07.06.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide compounds useful as inhibitors of ATR protein kinase.SOLUTION: The invention relates to compounds represented by formula I, and pharmaceutically acceptable compositions comprising the compounds. The invention also relates to methods of treating diseases such as cancer using the compounds. The invention also relates to processes for preparing the compounds. [Ris halo or the like; Ris H or the like; Rand Rare each independently H, halo, or the like; Ris Qor an aliphatic chain; and Qis a 3-7 membered fully saturated, partially unsaturated, or aromatic monocyclic ring.]SELECTED DRAWING: None 【課題】ＡＴＲプロテインキナーゼの阻害剤として有用な化合物の提供。【解決手段】式Iで表される化合物、及び前記化合物を含有する薬学的に受容可能な組成物。前記化合物を使用することによる、がん等の疾患の処置方法。前記化合物を調製するためのプロセス。［Ｒ１は、ハロ等；Ｒ９は、Ｈ等；Ｒ２及びＲ３は、各々独立にＨ、ハロ等；Ｒ４は、Ｑ１又は脂肪族鎖；Ｑ１は、３員〜７員の完全飽和、部分不飽和、もしくは芳香族の単環式環］【選択図】なし