DRUG EFFICACY MEASURING METHOD OF GASTRIC ACID INHIBITOR USING 13C CARBONATE

PROBLEM TO BE SOLVED: To provide a method for measuring drug efficacy of a gastric acid inhibitor to a mammal by using aC-labeled carbonate compound.SOLUTION: A method for measuring drug efficacy of a gastric acid inhibitor to a mammal has following steps: (1) a step for measuring a behavior ofCOdis...

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Main Authors INADA MUTSUMI, IIZUKA SHINJI, AKAMATSU MASARU, KUNISAKI JUNICHI, HIDA KAZUKI
Format Patent
LanguageEnglish
Japanese
Published 26.04.2018
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Abstract PROBLEM TO BE SOLVED: To provide a method for measuring drug efficacy of a gastric acid inhibitor to a mammal by using aC-labeled carbonate compound.SOLUTION: A method for measuring drug efficacy of a gastric acid inhibitor to a mammal has following steps: (1) a step for measuring a behavior ofCOdischarged in exhalation, by using, as a test sample, exhalation from a test mammal discharged at an optional point of time within 30 minutes after oral administration of aC-labeled carbonate compound as much as 10 mg-2 g, after administration of the gastric acid inhibitor, and (2) a step for measuring drug efficacy of the gastric acid inhibitor based on the behavior ofCOobtained in the step (1).SELECTED DRAWING: None 【課題】13C標識炭酸化合物を用いて哺乳動物に対する胃酸抑制剤の薬効を測定する方法を提供する【解決手段】下記の工程を有する哺乳動物に対する胃酸抑制剤の薬効を測定する方法である:(1)胃酸抑制剤の投与後、10mg〜2gの13C標識炭酸化合物が経口投与された後30分以内の任意の時点で排出された被験哺乳動物の呼気を被験試料として、当該呼気中に排出される13CO2の挙動を測定する工程、及び(2)工程(1)で得られた13CO2の挙動を元に、胃酸抑制剤の薬効を測定する工程。【選択図】なし
AbstractList PROBLEM TO BE SOLVED: To provide a method for measuring drug efficacy of a gastric acid inhibitor to a mammal by using aC-labeled carbonate compound.SOLUTION: A method for measuring drug efficacy of a gastric acid inhibitor to a mammal has following steps: (1) a step for measuring a behavior ofCOdischarged in exhalation, by using, as a test sample, exhalation from a test mammal discharged at an optional point of time within 30 minutes after oral administration of aC-labeled carbonate compound as much as 10 mg-2 g, after administration of the gastric acid inhibitor, and (2) a step for measuring drug efficacy of the gastric acid inhibitor based on the behavior ofCOobtained in the step (1).SELECTED DRAWING: None 【課題】13C標識炭酸化合物を用いて哺乳動物に対する胃酸抑制剤の薬効を測定する方法を提供する【解決手段】下記の工程を有する哺乳動物に対する胃酸抑制剤の薬効を測定する方法である:(1)胃酸抑制剤の投与後、10mg〜2gの13C標識炭酸化合物が経口投与された後30分以内の任意の時点で排出された被験哺乳動物の呼気を被験試料として、当該呼気中に排出される13CO2の挙動を測定する工程、及び(2)工程(1)で得られた13CO2の挙動を元に、胃酸抑制剤の薬効を測定する工程。【選択図】なし
Author IIZUKA SHINJI
AKAMATSU MASARU
INADA MUTSUMI
KUNISAKI JUNICHI
HIDA KAZUKI
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DocumentTitleAlternate 13C炭酸塩を用いた胃酸抑制剤の薬効測定方法
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Snippet PROBLEM TO BE SOLVED: To provide a method for measuring drug efficacy of a gastric acid inhibitor to a mammal by using aC-labeled carbonate compound.SOLUTION:...
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SubjectTerms BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
DIAGNOSIS
ENZYMOLOGY
GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC
GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS
HUMAN NECESSITIES
HYGIENE
IDENTIFICATION
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPIRITS
SURGERY
TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
TECHNICAL SUBJECTS COVERED BY FORMER USPC
TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
TESTING
VINEGAR
WINE
Title DRUG EFFICACY MEASURING METHOD OF GASTRIC ACID INHIBITOR USING 13C CARBONATE
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