DRUG EFFICACY MEASURING METHOD OF GASTRIC ACID INHIBITOR USING 13C CARBONATE

• Main Authors: INADA MUTSUMI, IIZUKA SHINJI, AKAMATSU MASARU, KUNISAKI JUNICHI, HIDA KAZUKI
• Format: Patent
• Language: English; Japanese
• Published: 26.04.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; DIAGNOSIS; ENZYMOLOGY; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; SURGERY; TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION; TECHNICAL SUBJECTS COVERED BY FORMER USPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE; TESTING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a method for measuring drug efficacy of a gastric acid inhibitor to a mammal by using aC-labeled carbonate compound.SOLUTION: A method for measuring drug efficacy of a gastric acid inhibitor to a mammal has following steps: (1) a step for measuring a behavior ofCOdischarged in exhalation, by using, as a test sample, exhalation from a test mammal discharged at an optional point of time within 30 minutes after oral administration of aC-labeled carbonate compound as much as 10 mg-2 g, after administration of the gastric acid inhibitor, and (2) a step for measuring drug efficacy of the gastric acid inhibitor based on the behavior ofCOobtained in the step (1).SELECTED DRAWING: None 【課題】13Ｃ標識炭酸化合物を用いて哺乳動物に対する胃酸抑制剤の薬効を測定する方法を提供する【解決手段】下記の工程を有する哺乳動物に対する胃酸抑制剤の薬効を測定する方法である：（１）胃酸抑制剤の投与後、１０ｍｇ〜２ｇの13Ｃ標識炭酸化合物が経口投与された後３０分以内の任意の時点で排出された被験哺乳動物の呼気を被験試料として、当該呼気中に排出される13ＣＯ２の挙動を測定する工程、及び（２）工程（１）で得られた13ＣＯ２の挙動を元に、胃酸抑制剤の薬効を測定する工程。【選択図】なし