DRUG EFFICACY MEASURING METHOD OF GASTRIC ACID INHIBITOR USING 13C CARBONATE
PROBLEM TO BE SOLVED: To provide a method for measuring drug efficacy of a gastric acid inhibitor to a mammal by using aC-labeled carbonate compound.SOLUTION: A method for measuring drug efficacy of a gastric acid inhibitor to a mammal has following steps: (1) a step for measuring a behavior ofCOdis...
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Main Authors | , , , , |
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Format | Patent |
Language | English Japanese |
Published |
26.04.2018
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Subjects | |
Online Access | Get full text |
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Summary: | PROBLEM TO BE SOLVED: To provide a method for measuring drug efficacy of a gastric acid inhibitor to a mammal by using aC-labeled carbonate compound.SOLUTION: A method for measuring drug efficacy of a gastric acid inhibitor to a mammal has following steps: (1) a step for measuring a behavior ofCOdischarged in exhalation, by using, as a test sample, exhalation from a test mammal discharged at an optional point of time within 30 minutes after oral administration of aC-labeled carbonate compound as much as 10 mg-2 g, after administration of the gastric acid inhibitor, and (2) a step for measuring drug efficacy of the gastric acid inhibitor based on the behavior ofCOobtained in the step (1).SELECTED DRAWING: None
【課題】13C標識炭酸化合物を用いて哺乳動物に対する胃酸抑制剤の薬効を測定する方法を提供する【解決手段】下記の工程を有する哺乳動物に対する胃酸抑制剤の薬効を測定する方法である:(1)胃酸抑制剤の投与後、10mg〜2gの13C標識炭酸化合物が経口投与された後30分以内の任意の時点で排出された被験哺乳動物の呼気を被験試料として、当該呼気中に排出される13CO2の挙動を測定する工程、及び(2)工程(1)で得られた13CO2の挙動を元に、胃酸抑制剤の薬効を測定する工程。【選択図】なし |
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Bibliography: | Application Number: JP20170215828 |