PROCESSES FOR THE PREPARATION OF PYRIMIDINYLCYCLOPENTANE COMPOUNDS

PROBLEM TO BE SOLVED: To provide processes for the preparation of pyrimidinylcyclopentane compounds which are useful as intermediates in the preparation of AKT protein kinase inhibitors with therapeutic activity against diseases such as cancer.SOLUTION: A preparation process includes coupling an opt...

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Bibliographic Details
Main Authors REINHARD REENTS, MICHELANGELO SCALONE, FRANCIS GOSSELIN, HANS IDING
Format Patent
LanguageEnglish
Japanese
Published 05.04.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide processes for the preparation of pyrimidinylcyclopentane compounds which are useful as intermediates in the preparation of AKT protein kinase inhibitors with therapeutic activity against diseases such as cancer.SOLUTION: A preparation process includes coupling an optically active carboxylic acid derivative produced by an asymmetric hydrogenation using a metal catalyst with an optically active alcohol derivative produced from an asymmetric reduction catalyzed by an oxidoreductase.SELECTED DRAWING: None 【課題】癌などの疾患に対する治療活性を有するＡＫＴプロテインキナーゼ阻害薬の調製における中間体として有用であるピリミジニルシクロペンタン化合物の調製方法の提供。【解決手段】金属触媒を用いた非対称水素化により製造される光学活性なカルボン酸誘導体と、酸化還元酵素によって触媒される非対称性還元により製造される光学活性なアルコール誘導体をカップリングさせる、調製方法。【選択図】なし
Bibliography:Application Number: JP20170222867