PLGA MICROPARTICLES, PLGA MICROPARTICLE PRODUCTION METHOD, AND PLGA MICROPARTICLE PRODUCTION APPARATUS

• Main Authors: YAMAGUCHI TATSUKI, SATO YUICHI, AOKI SHINJI, MORIYA ITSUKI, OGAKI TAKASHI, MORINAGA MASAHIKO
• Format: Patent
• Language: English; Japanese
• Published: 05.04.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

PROBLEM TO BE SOLVED: To provide PLGA microparticles suitable for filtration sterilization.SOLUTION: A PLGA microparticle contains lactic acid-glycolic acid copolymer (PLGA), in which relative Span Factor (R. S. F.) satisfies a formula (1) and an average volume-based particle diameter is 80 nm or less. 0<(R. S. F.)≤1.20...formula (1) [(R. S. F.) is defined by (D90-D10)/D50, D90 represents a cumulative 90 volume% from the small particle side of the cumulative particle size distribution, D50 represents a cumulative 50 volume% from the small particle side of the cumulative particle size distribution, D10 represents a cumulative 10 volume% from the small particle side of the cumulative particle size distribution.]SELECTED DRAWING: Figure 6 【課題】ろ過滅菌に適したＰＬＧＡ微粒子の提供。【解決手段】乳酸・グリコール酸共重合体（ＰＬＧＡ）を含有し、Ｒｅｌａｔｉｖｅ-Ｓｐａｎ-Ｆａｃｔｏｒ（Ｒ．Ｓ．Ｆ）が、式（１）を満たし、平均体積基準粒子径が、８０ｎｍ以下であるＰＬＧＡ微粒子。０＜（Ｒ．Ｓ．Ｆ）≦１．２０・・式（１）［（Ｒ．Ｓ．Ｆ）は（Ｄ９０−Ｄ１０）／Ｄ５０で定義され、Ｄ９０は、累積粒度分布の小粒子側からの累積９０体積％Ｄ５０は、累積粒度分布の小粒子側からの累積５０体積％を表し、Ｄ１０は、累積粒度分布の小粒子側からの累積１０体積％を表す。【選択図】図６