TETRACYCLINE DERIVATIVES FOR TREATMENT OF BACTERIAL, VIRAL AND PARASITIC INFECTIONS

PROBLEM TO BE SOLVED: To provide tetracycline derivatives for treatment of bacterial, viral and parasitic infections.SOLUTION: The present invention pertains, at least in part, to substituted tetracycline compounds of the formula (I), where X is CHC(RY'Y), CRR, C=CRR, S, NR, or O; E is NRR, OR,...

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Main Authors ABATO PAUL, BHATIA BEENA, PAN JINGWEN, HONEYMAN LAURA, BERNIAC JOEL, KIM OAK K, GRIER MARK, ISMAIL MOHAMED, ASSEFA HAREGEWEIN, VERMA ATUL, NELSON MARK, BOWSER TODD
Format Patent
LanguageEnglish
Japanese
Published 15.03.2018
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide tetracycline derivatives for treatment of bacterial, viral and parasitic infections.SOLUTION: The present invention pertains, at least in part, to substituted tetracycline compounds of the formula (I), where X is CHC(RY'Y), CRR, C=CRR, S, NR, or O; E is NRR, OR, or (CH)C(=W')WR; W is O, S, NR, or CRR; and W' is O, S, or NR. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.SELECTED DRAWING: None 【課題】細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体を提供すること。【解決手段】本発明は、少なくとも一部において、式（Ｉ）：（式中、Ｘは、ＣＨＣ（Ｒ１３Ｙ'Ｙ）、ＣＲ６'Ｒ６、Ｃ＝ＣＲ６'Ｒ６、Ｓ、ＮＲ６、またはＯであり；Ｅは、ＮＲ７ｄＲ７ｅ、ＯＲ７ｆまたは（ＣＨ２）０−１Ｃ（＝Ｗ'）ＷＲ７ｇであり；Ｗは、Ｏ、Ｓ、ＮＲ７ｈまたはＣＲ７ｉＲ７ｊであり；Ｗ'は、Ｏ、ＳまたはＮＲ７ｋである）の置換テトラサイクリン化合物に関する。これらのテトラサイクリン化合物は、数多くのテトラサイクリン化合物応答性状態、たとえば、細菌感染および新生物を治療するために使用することができる。【選択図】なし
Bibliography:Application Number: JP20170238683