NOVEL HETEROCYCLIC DERIVATIVE

• Main Authors: INOUE TSUTOMU, YAMOTO NORIKO, KATO HIROSHIGE, AMADA JUNICHIRO, TANIGUCHI TETSUYA, NAGAYAMA SACHIHO, INABA MASATO, YOSHINO YASUHIRO, SATO TAKAHIRO
• Format: Patent
• Language: English; Japanese
• Published: 15.03.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

PROBLEM TO BE SOLVED: To provide a novel compound which accelerates induction of differentiation of erythroid stem cells and has activity of accelerating production of erythropoietin, which is a glycoprotein hormone contributing to mature erythrocyte production.SOLUTION: The compound is represented by the general formula (1) in the figure. [X is O, N, S, a sulfinyl group, or a sulfonyl group; R1, R2 and R3 are each independently H or a C1-C6 alkyl group; R4 is H, a C1-C6 alkyl group, or an arylalkyl group; and R5 is a substituted/unsubstituted alkyl group, substituted/unsubstituted alkenyl group, substituted/unsubstituted aryl group, or the like.]SELECTED DRAWING: None 【課題】赤芽球系幹細胞の分化誘導を促進し、成熟赤血球の産生に寄与する糖蛋白質ホルモンであるエリスロポエチン産生促進作用を有する、新規化合物の提供。【解決手段】一般式（１）で示される化合物。［ＸはＯ、Ｎ、Ｓ、スルフィニル基、スルホニル基；Ｒ１、Ｒ２、Ｒ３は各々独立に、Ｈ又はＣ１−Ｃ６のアルキル基；Ｒ４はＨ、Ｃ１−Ｃ６のアルキル基、又はアリールアルキル基；Ｒ５は置換／非置換のアルキル基、又は置換／非置換のアルケニル基、又は置換／非置換のアリール基等］【選択図】なし