CHROMATOGRAPHY MATRICES INCLUDING NOVEL STAPHYLOCOCCUS AUREUS PROTEIN A BASED LIGANDS

PROBLEM TO BE SOLVED: To provide: chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, Staphylococcus aureus Protein A (SpA); and methods of using the same.SOLUTION: An affinity chromatography ligand comprises one or more C domains of Sta...

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Bibliographic Details
Main Authors ORLANDO JOE, BIAN NANYING, ROBERT SMITH, SPECTOR SHARI
Format Patent
LanguageEnglish
Japanese
Published 08.02.2018
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:PROBLEM TO BE SOLVED: To provide: chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, Staphylococcus aureus Protein A (SpA); and methods of using the same.SOLUTION: An affinity chromatography ligand comprises one or more C domains of Staphylococcus Protein A (SpA), where at least one C domain comprises a deletion of at least 3 consecutive amino acids from the N-terminus, starting at position 1 or at position 2.SELECTED DRAWING: None 【課題】スタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）プロテインＡ（ＳｐＡ）等の免疫グロブリン結合タンパク質の１つ以上のドメインをベースとするリガンドを含むクロマトグラフィーマトリックス、及びこれらを使用する方法の提供。【解決手段】１つ以上のスタフィロコッカスのプロテインＡ（ＳｐＡ）のＣドメインを含むアフィニティークロマトグラフィーリガンドであって、少なくとも１つのＣドメインが、位置１または位置２で始まる、Ｎ末端からの少なくとも３つの連続したアミノ酸の欠失を含む、アフィニティークロマトグラフィーリガンド。【選択図】なし
Bibliography:Application Number: JP20170148843