OCTAHYDRO FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS

PROBLEM TO BE SOLVED: To provide new compositions and new methods for modulating GR receptors.SOLUTION: The present invention provides octahydro fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators. In some embodiments, the present invention provides a...

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Bibliographic Details
Main Authors IAIN WALTERS, HAZEL HUNT, BENOIT GOURDET
Format Patent
LanguageEnglish
Japanese
Published 25.01.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide new compositions and new methods for modulating GR receptors.SOLUTION: The present invention provides octahydro fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators. In some embodiments, the present invention provides a pharmaceutical composition including a compound of the present invention and a pharmaceutically acceptable excipient. In some embodiments, the present invention provides a method of modulating a glucocorticoid receptor, the method including contacting a glucocorticoid receptor with a compound of the present invention, thereby modulating the glucocorticoid receptor.SELECTED DRAWING: None 【課題】ＧＲレセプターを調節するための新規組成物および新規方法を提供すること。【解決手段】本発明は、オクタヒドロ縮合アザデカリン化合物、およびその化合物を糖質コルチコイドレセプター調節因子として使用する方法を提供する。いくつかの実施形態において、本発明は、本発明の化合物および薬学的に許容され得る賦形剤を含む薬学的組成物を提供する。いくつかの実施形態において、本発明は、糖質コルチコイドレセプターを調節する方法を提供し、その方法は、糖質コルチコイドレセプターを本発明の化合物と接触させ、それによって、糖質コルチコイドレセプターを調節する工程を含む。【選択図】なし
Bibliography:Application Number: JP20170206081