PEPTIDE COMPOUND

• Main Authors: ASAMI TAIJI, NIIDA AYUMU
• Format: Patent
• Language: English; Japanese
• Published: 25.01.2018
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide a novel peptide compound having glucagon-like peptide-1 (GLP-1) receptor and glucose-dependent insulinotropic polypeptide (GIP) receptor activating actions, and use of the peptide compound as a medicine.SOLUTION: The present invention provides a peptide containing a partial sequence represented by formula (I) or a salt thereof, and a pharmaceutical composition containing the same. P-Tyr-Aib-Glu-Gly-Thr-α-MePhe-Thr-Ser-Asp-Tyr-Aib-A12-Aib-Leu-Asp-A16-A17-Ala-A19-Ala-Glu-Phe-Val-A24-Trp-Leu-Leu-A28-Gly(I)SELECTED DRAWING: None 【課題】グルカゴン様ペプチド−１（GLP-1）受容体及びグルコース依存症インスリン分泌刺激ポリペプチド（GIP）受容体活性化作用を有する新規ペプチド化合物、及び前記ペプチド化合物の医薬としての利用【解決手段】式（Ｉ）で表される部分配列を含有するペプチド又はその塩、及びこれを含む医薬組成物。Ｐ1−Ｔｙｒ−Ａｉｂ−Ｇｌｕ−Ｇｌｙ−Ｔｈｒ−α-ＭｅＰｈｅ−Ｔｈｒ−Ｓｅｒ−Ａｓｐ−Ｔｙｒ−Ａｉｂ−Ａ１２−Ａｉｂ−Ｌｅｕ−Ａｓｐ−Ａ１６−Ａ１７−Ａｌａ−Ａ１９−Ａｌａ−Ｇｌｕ−Ｐｈｅ−Ｖａｌ−Ａ２４−Ｔｒｐ−Ｌｅｕ−Ｌｅｕ−Ａ２８−Ｇｌｙ（Ｉ）【選択図】なし