UNIT STRUCTURE TYPE PHARMACEUTICAL COMPOSITION FOR NUCLEIC ACID DELIVERY

• Main Authors: MIYATA KANJIRO, NISHIYAMA NOBUHIRO, CHAYA HIROYUKI, TAKEMOTO HIROYASU, KATO YASUKI, OSADA KENSUKE, KATAOKA KAZUNORI, FUKUSHIMA SHIGETO, WATANABE SUMIYO
• Format: Patent
• Language: English; Japanese
• Published: 18.01.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide an improvement in blood retention performance of nucleic acid in a cationic polymer type carrier.SOLUTION: According to the present invention, there is a unit structure type pharmaceutical composition consisting of: one block copolymer having a cationic polyamino acid segment and a hydrophilic polymer chain segment; and one nucleic acid. The positive charge of the cationic polyamino acid segment and the negative charge of the nucleic acid cancel each other and are thus electrically neutral. The nucleic acid is covered with a hydrophilic polymer chain segment. The nucleic acid has a chain length of 10 to 30 bases. The block copolymer has a cationic polyamino acid segment and a poly (ethylene glycol) chain as the hydrophilic polymer chain segment disposed at one end of the cationic polyamino acid segment. The poly (ethylene glycol) chain has an inertial radius greater than or equal to the length of the nucleic acid.SELECTED DRAWING: None 【課題】カチオン性ポリマー型キャリアにおける核酸の血中滞留性能を向上性の提供。【解決手段】カチオン性ポリアミノ酸セグメントと親水性ポリマー鎖セグメントとを有する１つのブロックコポリマーと、１つの核酸と、からなり、該カチオン性ポリアミノ酸セグメントの正電荷と該核酸の負電荷とが相殺されて電気的に中性であり、該核酸が該親水性ポリマー鎖セグメントに覆われている、ユニット構造型医薬組成物であって、該核酸の鎖長が、１０〜３０塩基であり、該ブロックコポリマーが、カチオン性ポリアミノ酸セグメントと、該カチオン性ポリアミノ酸セグメントの片端に配置された該親水性ポリマー鎖セグメントとしてのポリ（エチレングリコール）鎖とを有し、該ポリ（エチレングリコール）鎖が、該核酸の長さ以上の慣性半径を有する、ユニット構造型医薬組成物。【選択図】なし