METHOD FOR DETECTING ENCEPHALOPATHY, BIOMARKER, COMPOSITION FOR DIAGNOSIS, AND KIT FOR DIAGNOSIS

• Main Authors: KOJIMA KARIN, YAMAGATA TAKANORI, ENDO HITOSHI, KUROIWA KENJI
• Format: Patent
• Language: English; Japanese
• Published: 11.01.2018
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

PROBLEM TO BE SOLVED: To provide a detection method for detecting a status epilepticus type (bi-phasic) acute encephalopathy (AESD).SOLUTION: Status epilepticus type (bi-phasic) acute encephalopathy is detected as an index of a change in an expression level in a cerebrospinal fluid of one protein of the group consisting of Monocyte differentiation antigen CD14, Apolipoprotein E, Gelsolin, Clusterin and α2-Macroglobulin. The detection is based on such phenomena that the expression level increases for the Monocyte differentiation antigen CD14, and the expression level decreases for the Apolipoprotein E, the Gelsolin, the Clusterin and the α2-Macroglobulin.SELECTED DRAWING: Figure 1 【課題】けいれん重積型（二相性）急性脳症（ＡＥＳＤ）を検出する検出方法を提供する。【解決手段】Ｍｏｎｏｃｙｔｅ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ａｎｔｉｇｅｎ ＣＤ１４、Ａｐｏｌｉｐｏｐｒｏｔｅｉｎ Ｅ、Ｇｅｌｓｏｌｉｎ、Ｃｌｕｓｔｅｒｉｎ、及びα２−Ｍａｃｒｏｇｌｏｂｕｌｉｎからなる群の一種のタンパク質の髄液中での発現量変化を指標として、けいれん重積型（二相性）急性脳症であることを検出する。この検出は、Ｍｏｎｏｃｙｔｅ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ａｎｔｉｇｅｎ ＣＤ１４については発現量が増加し、Ａｐｏｌｉｐｏｐｒｏｔｅｉｎ Ｅ、Ｇｅｌｓｏｌｉｎ、Ｃｌｕｓｔｅｒｉｎ、及びα２−Ｍａｃｒｏｇｌｏｂｕｌｉｎについては発現量が減少することに基づく。【選択図】図１