METHOD OF DETECTING THE EXISTENCE OF OSTEOPATHY, OSTEOPATHY THERAPEUTIC AGENT, AND METHOD FOR SCREENING OSTEOPATHY THERAPEUTIC AGENT

• Main Author: HII EIICHI
• Format: Patent
• Language: English; Japanese
• Published: 14.12.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To analyze the mechanism of occurrence of osteopathy in detail to provide a method of detecting osteopathy, an osteopathy therapeutic agent, and a method for screening an osteopathy therapeutic agent.SOLUTION: The inventors have completed the invention by newly discovering that Mek/Erk5/Smurf2/Smad/Sox9 cascade plays an important role in controlling skeleton formation (cartilage formation).SELECTED DRAWING: None 【課題】骨障害が生じる機構の詳細を解析して、骨障害の検出方法、骨障害の治療剤及び骨障害治療剤のスクリーニング方法を提供すること。【解決手段】Mek/Erk5/Smurf2/Smad/Sox9カスケードが骨格形成（軟骨形成）を制御するために重要な役割を有することを新規に見出し、本発明を完成した。【選択図】なし