METHOD FOR HIGHLY EXPRESSING TARGET PROTEIN FROM PLANTS USING RBCS FUSION PROTEIN AND METHOD FOR PREPARING A COMPOSITION FOR ORAL ADMINISTRATION OF MEDICAL PROTEIN USING PLANT BODY EXPRESSING TARGET PROTEIN

• Main Authors: KANG HYANG JU, SOHN EUN JU, HWANG INHWAN, PER OLOF BERGGREN, LEE YONG JIK, YOO YUN JOO, KIM JE YOUNG
• Format: Patent
• Language: English; Japanese
• Published: 24.11.2017
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW PLANTS OR PROCESSES FOR OBTAINING THEM; ORGANIC CHEMISTRY; PEPTIDES; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TRAPPING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a plant expressing a target protein, a production method thereof, and a method for producing a composition for oral administration of biopharmaceuticals using the same.SOLUTION: According to the present invention, there is provided a target protein expression system using plant cells. The system provides a method that solves a conventional problem of a plant cell culture. The method allows target proteins including a biopharmaceutical protein to be massively produced and simultaneously provides resistance to proteolytic enzymes present in the digestive organs. The system is therefore very effective to enable the commercialization of plant-derived biopharmaceuticals.SELECTED DRAWING: Figure 2 【課題】目的タンパク質を発現する植物、その製造方法及びこれを利用したバイオ医薬品経口投与用組成物製造方法を提供する。【解決手段】植物細胞を利用した目的タンパク質発現システムは、従来、植物細胞培養の問題点を解消し、バイオ医薬タンパク質を含む目的タンパク質を大量生産すると同時に、目的タンパク質が消化器官内に存在するタンパク質分解酵素に抵抗性を有するようにする方法を提供することによって、植物由来バイオ医薬品の商業化を可能にするのに非常に効果的である。【選択図】図２