POLYPEPTIDES AND POLYNUCLEOTIDES FOR TREATMENT OF IMMUNE RELATED DISORDERS AND CANCER, AND USES THEREOF

• Main Authors: AMIT NOVIK, AMIR TOPORIK, RONEN SHEMESH
• Format: Patent
• Language: English; Japanese
• Published: 09.11.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide novel therapeutic compositions and diagnostic compositions effective against ovarian cancer.SOLUTION: A therapeutic agent has the action to induce the apoptosis or lysis of a cancer cell that expresses LSR protein (lipolysis -stimulated lipoprotein receptor isoform 2, genbank accession number: NP_991403), by the involvement of CDC activity or ADCC activity of a monoclonal antibody, a polyclonal antibody or an antigen bond fragment thereof, having an antigen binding region that binds specifically to polypeptides.SELECTED DRAWING: None 【課題】卵巣がんに有効な新規のな治療用組成物および診断用組成物の提供。【解決手段】ポリペプチドに特異的に結合する抗原結合領域を有する、モノクローナル抗体、ポリクローナル抗体またはその抗原結合フラグメントのＣＤＣ活性またはＡＤＣＣ活性の関与により、ＬＳＲタンパク質（lipolysis-stimulated lipoprotein receptor isoform 2、ｇｅｎｂａｎｋ受託番号：ＮＰ＿９９１４０３）を発現するがん細胞のアポトーシスまたは溶解を誘導する作用を有する治療用薬剤。【選択図】なし