MODIFIED POLYNUCLEOTIDES FOR PRODUCING ONCOLOGY-RELATED PROTEINS AND PEPTIDES

• Main Authors: JASON P SCHRUM, PAUL HATALA, ANTONIN DE FOUGEROLLES, KENECHI EJEBE, MATTHIAS JOHN, SAYDA M ELBASHIR, ATANU ROY, JUSTIN GUILD, SUSAN WHORISKEY, TIRTHA CHAKRABORTY, STEPHANE BANCEL, KRISTY M WOOD, JEFF LYNN ELLSWORTH
• Format: Patent
• Language: English; Japanese
• Published: 02.11.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide methods for treating tumor-related diseases, disorders and/or conditions by administering oncology-related polynucleotides of specified sequences.SOLUTION: Provided is a method for treating a disease, disorder and/or condition in a subject in need thereof by increasing the level of an oncology-related polypeptide of interest, comprising administering to the subject an isolated and specified polynucleotide encoding the oncology-related polypeptide. Preferably, such a polynucleotide is modified mRNA (mmRNA).SELECTED DRAWING: None 【課題】腫瘍関連の特定配列ポリヌクレオチドの投与による、腫瘍関連の疾患、障害及び／又は状態を治療する方法の提供。【解決手段】目的の腫瘍関連ポリペプチドのレベルを高めることにより、疾患、障害、及び／又は状態の治療を必要とする対象の前記疾患、障害、及び／又は状態を治療する方法であって、前記腫瘍学関連ポリペプチドをコードする特定された単離ポリヌクレオチドを前記対象に投与することを含む方法。該ポリヌクレオチドとしては、修飾ｍＲＮＡ（ｍｍＲＮＡ）であることが好ましい【選択図】なし