ANDROGEN RECEPTOR MODULATORS AND USES THEREOF
PROBLEM TO BE SOLVED: To provide androgen receptor modulators for treating diseases or conditions that are mediated or dependent upon androgen receptors.SOLUTION: The present invention provides a compound represented by formula (VIIIa) (both Rtogether form C3-6 cycloalkyl or independently represent...
Saved in:
Main Authors | , , |
---|---|
Format | Patent |
Language | English Japanese |
Published |
02.11.2017
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | PROBLEM TO BE SOLVED: To provide androgen receptor modulators for treating diseases or conditions that are mediated or dependent upon androgen receptors.SOLUTION: The present invention provides a compound represented by formula (VIIIa) (both Rtogether form C3-6 cycloalkyl or independently represent H, OH, C1-6 alkyl or the like; X is O or S; Ris C1-6 alkyl or C1-6 fluoroalkyl; ring B is phenyl; n is an integer of 0-2; Ris halogen, -CN, -NO2, -OH or the like; Ris L-L-Ror L-R; Lis O, S, -O(C=O) or the like; Lis C1-6 alkylene; Rand Rare substituted/unsubstituted piperidinyl, substituted/unsubstituted morpholinyl, piperidinyl, or the like; Ris C1-6 alkyl, or C1-6 fluoroalkyl).SELECTED DRAWING: None
【課題】アンドロゲン受容体媒介性又は依存性である疾患又は疾病を処置するために、そのようなアンドロゲン受容体モジュレーターの提供。【解決手段】式(VIIIa)で表される化合物。(双方のR1は一諸にC3−6のシクロアルキル又は各々独立にH、OH、C1−6のアルキル等;XはO又はS;RAはC1−6のアルキル又はC1−6のフルオロアルキル;環Bはフェニル;nは0〜2の整数;R4はハロゲン、−CN、−NO2、−OH等;R5はL1−L2−R6又はL1−R7;L1はO、S、−O(C=O)等;L2はC1−6のアルキレン;R6及びR7は置換/非置換のピペリジニル、置換/非置換のモルホニル、ピペリジニル等;RAはC1−6のアルキル、又はC1−6のフルオロアルキル)【選択図】なし |
---|---|
AbstractList | PROBLEM TO BE SOLVED: To provide androgen receptor modulators for treating diseases or conditions that are mediated or dependent upon androgen receptors.SOLUTION: The present invention provides a compound represented by formula (VIIIa) (both Rtogether form C3-6 cycloalkyl or independently represent H, OH, C1-6 alkyl or the like; X is O or S; Ris C1-6 alkyl or C1-6 fluoroalkyl; ring B is phenyl; n is an integer of 0-2; Ris halogen, -CN, -NO2, -OH or the like; Ris L-L-Ror L-R; Lis O, S, -O(C=O) or the like; Lis C1-6 alkylene; Rand Rare substituted/unsubstituted piperidinyl, substituted/unsubstituted morpholinyl, piperidinyl, or the like; Ris C1-6 alkyl, or C1-6 fluoroalkyl).SELECTED DRAWING: None
【課題】アンドロゲン受容体媒介性又は依存性である疾患又は疾病を処置するために、そのようなアンドロゲン受容体モジュレーターの提供。【解決手段】式(VIIIa)で表される化合物。(双方のR1は一諸にC3−6のシクロアルキル又は各々独立にH、OH、C1−6のアルキル等;XはO又はS;RAはC1−6のアルキル又はC1−6のフルオロアルキル;環Bはフェニル;nは0〜2の整数;R4はハロゲン、−CN、−NO2、−OH等;R5はL1−L2−R6又はL1−R7;L1はO、S、−O(C=O)等;L2はC1−6のアルキレン;R6及びR7は置換/非置換のピペリジニル、置換/非置換のモルホニル、ピペリジニル等;RAはC1−6のアルキル、又はC1−6のフルオロアルキル)【選択図】なし |
Author | JACKALINE D JULIEN CELINE BONNEFOUS NICHOLAS D SMITH |
Author_xml | – fullname: CELINE BONNEFOUS – fullname: NICHOLAS D SMITH – fullname: JACKALINE D JULIEN |
BookMark | eNrjYmDJy89L5WTQdfRzCfJ3d_VTCHJ1dg0I8Q9S8PV3CfVxBLKCFYCSCqHBrsEKIR6uQa7-bjwMrGmJOcWpvFCam0HJzTXE2UM3tSA_PrW4IDE5NS-1JN4rwMjA0NzQ0tzU2MLRmChFAAxnJ9g |
ContentType | Patent |
DBID | EVB |
DatabaseName | esp@cenet |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Sciences |
DocumentTitleAlternate | アンドロゲン受容体モジュレーターおよびその使用 |
ExternalDocumentID | JP2017197538A |
GroupedDBID | EVB |
ID | FETCH-epo_espacenet_JP2017197538A3 |
IEDL.DBID | EVB |
IngestDate | Fri Aug 23 06:57:05 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English Japanese |
LinkModel | DirectLink |
MergedId | FETCHMERGED-epo_espacenet_JP2017197538A3 |
Notes | Application Number: JP20170091441 |
OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171102&DB=EPODOC&CC=JP&NR=2017197538A |
ParticipantIDs | epo_espacenet_JP2017197538A |
PublicationCentury | 2000 |
PublicationDate | 20171102 |
PublicationDateYYYYMMDD | 2017-11-02 |
PublicationDate_xml | – month: 11 year: 2017 text: 20171102 day: 02 |
PublicationDecade | 2010 |
PublicationYear | 2017 |
RelatedCompanies | ARAGON PHARMACEUTICALS INC |
RelatedCompanies_xml | – name: ARAGON PHARMACEUTICALS INC |
Score | 3.2349508 |
Snippet | PROBLEM TO BE SOLVED: To provide androgen receptor modulators for treating diseases or conditions that are mediated or dependent upon androgen... |
SourceID | epo |
SourceType | Open Access Repository |
SubjectTerms | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
Title | ANDROGEN RECEPTOR MODULATORS AND USES THEREOF |
URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171102&DB=EPODOC&locale=&CC=JP&NR=2017197538A |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED_mFPVNp6JOJYj0LVjXzLYPRboktRTXltrK3kbbVVBBh6v473uNne5pb5cc5AvufnfJ3QXgCjEIQcsY0OcqtykzWEERxw2q27lpsBIt7lIFyIa3fsaCyXDSgbdlLoyqE_qtiiOiRJUo77XS1_P_SyyhYisX18ULdn3ceakjtNY7vjERzQaaGDkyjkTENc6dINbC5JfXJJFa7gZsNnZ0U2hfPo2atJT5KqZ4e7AV43Dv9T50XvMe7PDl12s92B63L95ItsK3OADqhiKJ7mVIEsllnEYJGUcie3CReiTIJBkqR5L6MpGRdwiXnky5T3He6d8up0G8skbjCLro_lfHQGYlY5Vu5hY6GniWul0OLbuaMbQDdFZa-Qn01wx0upbbh92mpXLrBmfQrT-_qnME2bq4UIfzA20ieeQ |
link.rule.ids | 230,309,786,891,25594,76906 |
linkProvider | European Patent Office |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT4MwEL_MaZxvOjXT-UGM4Y2I0Ak8EMOgiAiUIDN7I8AwURNdHMZ_36My3dPeLr3k2l5y97tre1eAS8QgBC1VkZ6r3JCISgoJcVyVZCPXVFJixF3yB7LRjTch_nQ07cDbshaG9wn95s0R0aJKtPea--v5_yGWw99WLq6KFxz6uHVT0xHb7PhaQzRTRGds0pg5zBZt2_RjMUp-eU0RqW5twKbWtOdtYqencVOWMl_FFHcXtmIU917vQec170PPXn691oftsL3xRrI1vsU-SFbkJOyORkJCbRqnLBFC5kwCC6lHAZnCBJ2jkHo0ocw9gAuXprYn4bzZ3y4zP15Zo3oIXUz_qwEIs5KQStZyHRMN1KVslCPdqGYE4wCZlHp-BMM1go7Xcs-h56VhkAX30cMQdhoOr7NTTqBbf35Vpwi4dXHGFfUDSLB80Q |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=ANDROGEN+RECEPTOR+MODULATORS+AND+USES+THEREOF&rft.inventor=CELINE+BONNEFOUS&rft.inventor=NICHOLAS+D+SMITH&rft.inventor=JACKALINE+D+JULIEN&rft.date=2017-11-02&rft.externalDBID=A&rft.externalDocID=JP2017197538A |