ANDROGEN RECEPTOR MODULATORS AND USES THEREOF

• Main Authors: CELINE BONNEFOUS, NICHOLAS D SMITH, JACKALINE D JULIEN
• Format: Patent
• Language: English; Japanese
• Published: 02.11.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide androgen receptor modulators for treating diseases or conditions that are mediated or dependent upon androgen receptors.SOLUTION: The present invention provides a compound represented by formula (VIIIa) (both Rtogether form C3-6 cycloalkyl or independently represent H, OH, C1-6 alkyl or the like; X is O or S; Ris C1-6 alkyl or C1-6 fluoroalkyl; ring B is phenyl; n is an integer of 0-2; Ris halogen, -CN, -NO2, -OH or the like; Ris L-L-Ror L-R; Lis O, S, -O(C=O) or the like; Lis C1-6 alkylene; Rand Rare substituted/unsubstituted piperidinyl, substituted/unsubstituted morpholinyl, piperidinyl, or the like; Ris C1-6 alkyl, or C1-6 fluoroalkyl).SELECTED DRAWING: None 【課題】アンドロゲン受容体媒介性又は依存性である疾患又は疾病を処置するために、そのようなアンドロゲン受容体モジュレーターの提供。【解決手段】式（ＶＩＩＩａ）で表される化合物。（双方のＲ１は一諸にＣ３−６のシクロアルキル又は各々独立にＨ、ＯＨ、Ｃ１−６のアルキル等；ＸはＯ又はＳ；ＲＡはＣ１−６のアルキル又はＣ１−６のフルオロアルキル；環Ｂはフェニル；ｎは０〜２の整数；Ｒ４はハロゲン、−ＣＮ、−ＮＯ２、−ＯＨ等；Ｒ５はＬ１−Ｌ２−Ｒ６又はＬ１−Ｒ７；Ｌ１はＯ、Ｓ、−Ｏ（Ｃ＝Ｏ）等；Ｌ２はＣ１−６のアルキレン；Ｒ６及びＲ７は置換／非置換のピペリジニル、置換／非置換のモルホニル、ピペリジニル等；ＲＡはＣ１−６のアルキル、又はＣ１−６のフルオロアルキル）【選択図】なし