VARIANT ACTIVIN RECEPTOR POLYPEPTIDES, ALONE OR IN COMBINATION WITH CHEMOTHERAPY, AND USES THEREOF

• Main Authors: SUN JEONGHOON, KEITH SOO-NYUNG KWAK, LEI-TING TONY TAM, HAN HUIQUAN, ZHOU XIAOLAN
• Format: Patent
• Language: English; Japanese
• Published: 05.10.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide agents for treating cancer.SOLUTION: The present invention provides pharmaceutical compositions comprising: soluble variant activin IIB receptor polypeptides and variant activin IIB receptor proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11; and chemotherapeutic agents including 5-fluorouracil (5-FU). The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and the variant proteins.SELECTED DRAWING: None 【課題】癌の治療剤の提供。【解決手段】アクチビンA、ミオスタチン、またはGDF-11を結合させてそれらの活性を阻害することができる可溶性の変異アクチビンIIB受容体ポリペプチドおよび変異アクチビンIIB受容体タンパク質と、5-フルオロウラシル（5-FU）を含む化学療法剤とを含む薬学的組成物。変異ポリペプチドおよび該変異タンパク質を産生することができる、ポリヌクレオチド、ベクター、および宿主細胞の提供。【選択図】なし