HAIR WHITENING INHIBITOR, CELL DEATH INHIBITOR, ACTIVE OXYGEN GENERATION INHIBITOR, DNA DAMAGE INHIBITOR, AND MITOCHONDRIAL DAMAGE INHIBITOR

• Main Authors: TAGUCHI NOBUHIKO, KUNISADA TAKAHIRO, KAMIYA EMI, AOKI HITOMI, KOBAYASHI AI
• Format: Patent
• Language: English; Japanese
• Published: 28.09.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS

PROBLEM TO BE SOLVED: To provide an excellent hair whitening inhibitor using a flavonoid capable of inhibiting cell death, the generation of intracellular active oxygen, DNA damage, and mitochondrial damage from factors which induce hair whitening such as radiation, ultraviolet rays, and oxidative stress.SOLUTION: The hair whitening inhibitor comprises 3',4',5-trihydroxy-7-methoxyflavone represented in chemical formula (1) as a flavonoid, preferably in the amount of 0.0001 to 1.0 mass%.SELECTED DRAWING: None 【課題】放射線や紫外線、老化、酸化ストレス等の白毛化を誘発する因子から細胞死、細胞内の活性酸素の発生、ＤＮＡ損傷、ミトコンドリア損傷を抑制することができる、フラボノイド類を用いた優れた白毛化抑制剤を提供。【解決手段】フラボノイド類の中で、化式（１）で表される３'，４'，５−トリヒドロキシ−７−メトキシフラボンを好ましくは０．０００１〜１．０質量％含有する白毛化抑制剤。【選択図】なし