FURTHER NOVEL FORMS OF INTERFERING RNA MOLECULES

• Main Authors: KAUFMANN JOERG, GIESE KLAUS, ANKE KLIPPEL-GIESE
• Format: Patent
• Language: English; Japanese
• Published: 21.09.2017
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; NEW PLANTS OR PROCESSES FOR OBTAINING THEM; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; SUGARS; TRAPPING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide further novel forms of interfering RNA molecules which are stable and active in a biochemical environment such as a living cell.SOLUTION: Provided is a ribonucleic acid comprising a double stranded structure, where the double stranded structure comprises a first strand and a second strand, the first strand comprises a first stretch of contiguous nucleotides, and the first stretch is at least partially complementary to a target nucleic acid, the second strand comprises a second stretch of contiguous nucleotides where the second stretch is at least partially identical to the target nucleic acid, and the double stranded structure is blunt ended.SELECTED DRAWING: None 【課題】生細胞の様な生物化学的環境内において、安定かつ活性である、より新規形態の干渉ＲＮＡ分子の提供。【解決手段】２本鎖構造を含むリボ核酸であって、前記２本鎖構造が第１鎖及び第２鎖を含み、この時第１鎖は連続ヌクレオチドの第１ストレッチを含み、そして前記第１ストレッチは標的核酸と少なくとも部分的に相補的であり、また前記第２鎖は連続ヌクレオチドの第２ストレッチを含み、このとき前記第２ストレッチは標的核酸と少なくとも部分的に同一であるものであり、そして前記２本鎖構造が平滑端を有するものであるリボ核酸。【選択図】なし