NALFURAFINE-CONTAINING ORALLY DISINTEGRATING TABLET

• Main Authors: OGAWA YOSHIYUKI, OGIWARA SATORU
• Format: Patent
• Language: English; Japanese
• Published: 10.08.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide nalfurafine-containing orally disintegrating tablets having high stability even after storage in various conditions.SOLUTION: A nalfurafine-containing orally disintegrating tablet of the present invention is characterized by containing nalfurafine, trehalose, low substituted hydroxypropylcellulose, and L-leucine or sucrose fatty acid ester. The tablet may contain 7% by weight or more to 10% by weight or less of trehalose per 1-tablet 100% by weight, and may contain 10% by weight of more to 14% by weight or less of low substituted hydroxypropylcellulose per 1-tablet 100% by weight.SELECTED DRAWING: None 【課題】各種条件下で保存した後であっても安定性の高いナルフラフィン含有口腔内崩壊錠を提供することを目的とする。【解決手段】本発明のナルフラフィン含有口腔内崩壊錠は、ナルフラフィンと、トレハロースと、低置換度ヒドロキシプロピルセルロースと、Ｌ−ロイシンまたはショ糖脂肪酸エステルとを含有することを特徴とする。また、トレハロースを１錠１００重量％当たり７重量％以上１０重量％以下含んでもよい。また、低置換度ヒドロキシプロピルセルロースを１錠１００重量％当たり１０重量％以上１４重量％以下含んでもよい。【選択図】なし