2'-FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT

• Main Authors: CHO AESOP, KIM CHOUNG, ADRIAN RAY
• Format: Patent
• Language: English; Japanese
• Published: 06.07.2017
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment.SOLUTION: Provided are selected imidazo[1,2-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, where the 2' position of the nucleoside sugar is substituted with halogen and carbon substituents. The compounds, compositions and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections caused by both wild type and mutant strains of HCV.SELECTED DRAWING: None 【課題】抗ウイルス治療用の２'−フルオロ置換カルバヌクレオシド類似体の提供。【解決手段】ヌクレオシド糖の２'位がハロゲンおよび炭素置換基に置換されている、選択されたイミダゾ［１，２−ｆ］［１，２，４］トリアジニルヌクレオシド、リン酸ヌクレオシドおよびそれらのプロドラッグを提供する。提供される化合物、組成物および方法はフラビウイルス感染、特にＨＣＶの野生型および突然変異株の両方に起因するＣ型肝炎感染治療に有用である。【選択図】なし