SUBSTITUTED AZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES

• Main Authors: SHIGETA YUKIHIRO, SHINTANI YUSUKE, NIWA MASATOSHI, SHIMAZAWA YOSHINOBU, MOMMA SOICHI, ISHIYAMA KIYOSHI
• Format: Patent
• Language: English; Japanese
• Published: 06.07.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide a novel substituted azole compound that has a GPR119 activating action and is useful for preventing and/or treating diabetes or obesity.SOLUTION: There is provided a novel substituted azole compound represented by Formula (I), a tautomer or pharmaceutically acceptable salt of the compound, or a solvate thereof, wherein ring A is a Caromatic hydrocarbon ring or a 5-10 membered heteroaromatic ring; ring B is a heterocyclic ring represented by Formula (II); ring C is benzene ring or a 5-6 membered heteroaromatic ring; Ris H, Chaloalkyl group or the like; Ris a Chaloalkyl group or a Calkyl group and Rand Rmay form a cycloalkyl ring; Rand Rare H, a Calkyl group or the like; or a Ccycloalkyl group or the like and Rand Rmay form a heterocyclyl ring.SELECTED DRAWING: None 【課題】ＧＰＲ１１９活性化作用を有し、糖尿病、肥満の予防及び／又は治療に有用な、新規置換アゾール化合物の提供。【解決手段】式（Ｉ）で表される新規置換アゾール化合物、該化合物の互変異性体若しくはその医薬的に許容され得る塩又はそれらの溶媒和物。（環ＡはＣ６−１０の芳香族炭化水素環又は５−１０員芳香族複素環；環Ｂは式（ＩＩ）で示される複素環；環Ｃはベンゼン環又は５−６員芳香族複素環；Ｒ１はＨ、Ｃ１−６のハロアルキル基等；Ｒ２はＣ１−６のハロアルキル基又はＣ１−６のアルキル基でＲ１とＲ２がシクロアルキル環を形成しても良い；Ｒ３及びＲ４はＨ、Ｃ１−６のアルキル基等；Ｃ３−６のシクロアルキル基等でＲ３とＲ４がシクロヘテロ環を形成しても良い）【選択図】なし