POLYMER FACTOR IX MOIETY CONJUGATES

PROBLEM TO BE SOLVED: To provide more simple processes for conjugating a polymer to a moiety having Factor IX activity.SOLUTION: Conjugates of a Factor IX moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is polyethylene glycol or a derivative thereof....

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Bibliographic Details
Main Authors STEPHENSON GAYLE, BOSSARD MARY J
Format Patent
LanguageEnglish
Japanese
Published 15.06.2017
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide more simple processes for conjugating a polymer to a moiety having Factor IX activity.SOLUTION: Conjugates of a Factor IX moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is polyethylene glycol or a derivative thereof. Also provided (among other things) are compositions comprising the conjugates, methods of making the conjugates, and methods of administering to a patient compositions comprising the conjugates.SELECTED DRAWING: Figure 1 【課題】第ＩＸ因子活性を有する部分に高分子を抱合するためのより単純なプロセスを提供。【解決手段】ＩＸ因子部分および１つ以上の水溶性高分子の抱合体を提供することによる。一般に、水溶性高分子は、ポリエチレングリコールまたはその誘導体である。また、（とりわけ）抱合体を含む組成物、抱合体の生成方法、および抱合体を含む組成物の患者への投与方法も提供する。【選択図】図１
Bibliography:Application Number: JP20170022364